Effects of Toxicity On The Body



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Overview
Endocrine Disrupting Chemicals
Heavy Metal Toxicity
     Overview
     Metallothionein
     Porphyrins and Heme Production
     Increase in Free Radical Production
     Displacement of Nutritional Metals
     Effects of Mercury
     Other Heavy Metals
     Effects of Individual Heavy Metals
Hydrogen Sulphide Build Up
Lipofuscin Build Up
Sensitivity to Heavy Metals and other Neurotoxins
Multiple Chemical Sensitivities
Skin Elasticity and the 'Fountain of Youth'
 


 
Overview:

Toxins are called toxins because they are toxic! This may sound obvious and patronising, but it must be clearly stated. To be nonchalant about the level of toxins in one's body is unwise. There is no good reason to insist on keeping all the toxins absorbed over time, whilst accumulating more and more with age. They are not our friends or desirable or pleasurable. They should not be there and cause huge damage to our biochemical functioning. If you care about your car, you would not leave dirty and old oil in the engine would you? How much more should you have 'clean mechanicals' inside your body!

Harmful phases of toxins tend to be fat soluble (lipophilic) and attach themselves to the lipid compartments (fat/lipid molecules) in the body. They are hard to remove from these places and are also difficult to transport across cell membranes for excretion. Toxins that are not effectively cleared from the body by the liver and kidneys thus end up usually in two places:

An article 'The Detoxx System: Detoxification of Biotoxins in Chronic Neurotoxic Syndrome' [a.k.a. Neurotoxic Membrane Syndrome] by John Foster, M.D., Patricia Kane, Ph.D., Neal Speight, M.D. is shown at the link below.

http://articles.mercola.com/sites/articles/archive/2003/08/09/detoxification-biotoxins.aspx

A toxified body is unlikely to function optimally and the affected person will not naturally feel as good as he would otherwise (not jumping out of bed every morning!) This is partly on account of mitochondrial inefficiency and the compromising of the mitochondrial membranes with toxins and partial detoxification products, but also the displacement effect that toxic metals also have on the essential minerals in our bodies.

The immune system is particularly affected. It is clear that we are born with a certain amount of toxins from our mothers but accumulate more and more over time during our lives. Detoxifying the body is likely to help to balance the immune system in those with auto-immune system disorders and to enhance the immune system of those with an impaired immune system. It is also likely to aid in weight loss, as the fats that are required by the body to bind with toxins are no longer required.

People may associate obese or overweight people with toxins, and slim, skinny people with being clean and toxin free. Whilst various types of toxins attach themselves most readily to fatty tissues in the body, the slender, athletic person still has plenty of fatty tissues and cell membranes for toxins to attach themselves to. So the body type is not so important as far as a toxicity perspective goes. However, which body type is easiest to detoxify is another matter.

Every person's body reacts differently to toxicity. Establishing in absolute terms the levels of heavy metals in a person's tissues or blood is only so useful, as a 'low' level may have a negligible effect in one person and a huge debilitating effect in another. The reaction to a particular toxin is dependent in part to the individual's immune system's response to the presence of that particular level of that particular chemical in the blood stream. The definitions of what constitutes 'low' and 'significant' levels vary from agency to specialist. In reality, no level of toxicity is a good thing. If you can 'get away' with something, that doesn't mean you should necessarily ignore it. It is good practice to avoid ingesting/taking in toxins if possible, and to help the body eliminate those we have accumulated, not only those that interfere with the body's core processes, but also those that by default cause oxidative damages to our cells and premature ageing, and those that are carcinogenic and may cause various forms of cancer in later life.

For a sufferer of CFS or related conditions, the effects of toxicity on an already poorly functioning biochemistry can be very significant indeed. I would suggest that every person suffering from CFS or related conditions should rule toxicity out of the equation of their health problems, and the only way to actually to do that with 100% certainty is to perform a full bodily detoxification programme. In the normal course of treatment, this is performed after harmful micro-organisms have been eliminated from the body. With the presence of large numbers of harmful micro-organisms, heavy metals and biotoxins, the body is unlikely to recover, even when all the other root causes are being effectively targetted.

Please see the Introduction section on the Liver Function page regarding the effect of toxins on the body and in particular toxin accumulation and liver function.

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Endocrine Disrupting Chemicals:

Please see below a list of chemicals (including pesticides, domestic products, foreign hormones and industrial chemicals) that are classified as 'Endocrine Disrupting Chemicals'. These then have a negative disruptive effect on the body's endocrine system glands and disrupt the normal hormonal functioning of the body, by either mimicking or inhibiting the body's hormones. Hormones are the regulatory chemicals in the body. In some animals, such as frogs, birds, fish and molluscs, they have produced infertility and gender changes. For more information on the Endocrine system, and Endocrine system imbalance, please see the a href="adrenal.html">Hormonal page.

www.foe.co.uk/resource/briefings/endocrine_disrupting.html

http://website.lineone.net/~mwarhurst/chemicals.html

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Heavy Metal Toxicity:
 

Early physiological signs of Mercury toxicity or contamination include:

A worsening and development of symptoms from moderate or chronic exposure to Mercury may include:

Advanced disease symptoms and processes from Mercury toxicity may include:

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Other Heavy Metals:

Below is some test report data on a few selected heavy metals. A broader overview of (virtually) all heavy metals can be found in the next section.

According to Trace Minerals International's Toxic Metals Chart, www.tracemin.com:

According to Doctor's Data, Urine Toxics Metals report, based on various reference sources:

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Overview of Effects of Individual Heavy Metals:

Please see the following chart, provided by Genova Diagnostics, for a list of toxic elements, their sources and their effects. It examines Aluminium, Antimony, Arsenic, Barium, Bismuth, Cadmium, Caesium, Gallium, Gadolinium, Germanium, Lead, Mercury, Nickel, Niobium, Platinum, Rhodium, Tellurium, Thallium and Thorium.

http://www.metametrix.com/files/test-menu/interpretive-guides/Elements-IG.pdf

Simply left click, or right click and select 'Save Target'). Viewing this chart requires Adobe Reader. If you do not have this, please download it from the following link.

http://www.adobe.com/products/acrobat/readstep2.html

Please click on the link below for a view of the periodic table, where you can see how the elements all fit together. Chemistry becomes fun when you can apply it directly to yourself!

Periodic Table at www.Chemicool.com

Please see also the web sites below for information pertaining to the effects of different toxic metals. www.tuberose.com/Heavy_Metal_Toxicity.html

www.energywave.com/environmental-issues/toxins/metal-toxicity.htm

www.mercurypoisoningfree.com/page/1186180

The US Centers for Disease Control and Prevention's web site contains useful information about the toxic metals Arsenic, Barium, Mercury and Thallium.

http://www.bt.cdc.gov/agent/metals/

Additional information can be found on Wikipedia of course.

http://en.wikipedia.org/wiki/Mercury_poisoning

'Symptoms [of Mercury poisoning] typically include sensory impairment (vision, hearing, speech), disturbed sensation and a lack of coordination. The type and degree of symptoms exhibited depend upon the individual toxin, the dose, and the method and duration of exposure.'

http://en.wikipedia.org/wiki/Arsenic_poisoning

'Arsenic poisoning interferes with cellular longevity by allosteric inhibition of an essential metabolic enzyme pyruvate dehydrogenase (PDH) complex which catalyzes the reaction Pyruvate + CoA-SH + NAD+ PDH Acetyl-Co-A + NADH + CO2 [i.e. energy production or metabolism]. With the enzyme inhibited, the energy system of the cell is disrupted resulting in an apoptosis episode. Arsenic in cells clearly stimulates the production of hydrogen peroxide (H2O2). When the H2O2 reacts with Fenton metals such as iron, it produces a highly reactive hydroxyl radical. Inorganic Arsenic trioxide found in ground water particularly affects Voltage-gated potassium channels , [1] disrupting cellular electrolytic function resulting in neurological disturbances, cardiovascular episodes such as prolonged qt interval, high blood pressure [2] central nervous system dysfunction and death. Arsenic trioxide is a ubiquitous element present in American drinking water.'

http://en.wikipedia.org/wiki/Lead_poisoning

'Lead poisoning (also known as plumbism, colica pictonium, saturnism, Devon colic, or painter's colic) is a medical condition caused by increased levels of the heavy metal lead in the body. Lead interferes with a variety of body processes and is toxic to many organs and tissues including the heart, bones, intestines, kidneys, and reproductive and nervous systems. It interferes with the development of the nervous system and is therefore particularly toxic to children, causing potentially permanent learning and behavior disorders. Symptoms include abdominal pain, headache, anemia, irritability, and in severe cases seizures, coma, and death.'

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Hydrogen Sulphide build up:

One example of an effect of insufficient Phase 1 oxidative enzymes, i.e. Cytochrome P450 enzymes, is the potential build up of Hydrogen Sulphide in the mitochondria, resulting in inefficient mitochondrial functioning and oxygen respiration, and general fatigue.

An example of exotoxins produced by bad bacteria, parasites and fungi includes Hydrogen Sulphide (Sulfide in the USA), or H2S.

As stated below in the Sources of Exogenous Toxins section, on the Bacterial Overgrowth page and Mitochondrial Dysfunction page, Hydrogen Sulphide (H2S) is an exotoxin produced in the body by the action of bad bacteria and fungi (such as Candida Albicans) fermenting sugar in the gastrointestinal tract. H2S is also natural by product of various bodily processes (e.g. produced by brain, pancreas and GI tract) and it plays a part in regulating the blood pressure, body temperature, vascular smooth muscle,cardiac function, cerebral ischemia, and in modulating the hypothalamus/pituitary/adrenal axis.

Since hydrogen sulfide occurs naturally in the environment and the gut, enzymes exist in the body capable of detoxifying it by oxidation to (harmless) sulfate. Hence low levels of sulfide may be tolerated indefinitely. Humans can smell the odour of hydrogen sulfide at 0.02 ppm. The toxicity of H2S is comparable with that of Hydrogen Cyanide. H2S is characterised by the 'rotten eggs' smell at low gaseous concentrations. Levels of H2S are normally regulated by the body's oxidative enzymes.

Elevated levels of H2S in the blood and tissues, that the body's oxidative enzymes cannot effectively deal with (or being overwise engaged with oxiding drugs and other chemical toxins from the blood in addition to the additional H2S), can result in mitochondrial dysfunction by their action on the Cytochrome C Oxidase enzyme which is involved in ATP production. It forms a complex bond with iron in the mitochondrial cytochrome enzymes, thereby blocking oxygen from binding and stopping cellular respiration.

Recent research has shown that even at low, non-toxic doses, H2S produces a reversible state of hibernation-like deanimation in mice, causing a decrease in core body temperature, an apnea-like sleep state, decreased heart and respiration rates and a severe metabolic drop.

http://en.wikipedia.org/wiki/Hydrogen_sulfide

Hypothesis: Is ME/CFS caused by dysregulation of hydrogen sulfide metabolism? (2008) by Marian Dix Lemle

www.beatcfsandfms.org

www.prohealth.com/library/showarticle.cfm?libid=14579

Treatment of severe (toxic and immediately life threatening) cases of Hydrogen Sulphide poisoning (in industrial applications) involves immediate inhalation of amyl nitrite (i.e. 'poppers'!), injections of sodium nitrite (both powerful vasodilators), inhalation of pure oxygen, administration of bronchodilators to overcome eventual bronchospasm, and in some cases hyperbaric oxygen therapy (HBO). HBO therapy has anecdotal support and remains controversial.

With regards to dealing with cases of low (non-toxic) levels of Hydrogen Sulphide poisoning in the body's mitochondria, for example that which arises as exotoxins produced by bad bacteria, fungi and parasites in the digestive tract over long periods of time, then treatment options may include boosting the body's natural oxidative enzyme count and assisting liver functioning; cutting out toxins and drugs that require removal by the Cytochrome P450 enzymes (i.e. alleviating the burden on these enzymes to allw them to focus on removing the H2S movlecules); removing the source of the additional exotoxins (i.e. eliminating the bad bacterial/fungal/parasitic overgrowth that is producing the extra H2S); and proper breathing (i.e. diaphragm breathing rather that the shallow breathing that is typified by use of the rig cage only). Oxygen therapy and even hyperbaric therapy may well be useful too. As mentioned on the Causes and Effects page, I have Technical/Decompression Diving certification and have access to oxygen tanks, and I found that breathing this for short periods of time (on dry land!) considerably helped me feel better and more oxygenated, as if I was breathing before but not getting the oxygen to the tissues and taking part in respiration in sufficient quantities. If one is breathing correctly, with fresh air, regularly, then one cannot really do much more than this, other than raise the oxygen content of the gas one is breathing. Proper breathing is also very important for general health, to expel enough CO2 (raising one's pH and avoiding Acidosis and to raise the blood O2 levels in the haemoglobin in the red blood cells to high enough levels. For low levels of H2S poisoning, it is not recommended to use vasodilators, as one's condition is not life threatening and dilating the blood vessels like this is too severe a solution, the vasodilator chemicals themselves having various adverse effects on the body and being poisons themselves.

Elevated bodily Hydrogen Sulphide levels are said to result in elevated levels of Hydrogen Sulphide in the urine, according to Kenny De Meileir, which forms the basis of a new 2009 home test by Protea Biopharma.

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Lipofuscin Build Up

Lipofuscin, a.k.a. lipopigment, is a type of yellow-brown fine pigment granule, comprised of lipid-containing residues of lysosomal digestion. Lysosomes are cellular organelles (separate intracellular substructures) that contain hydrolase enzymes to break up waste materials and cellular debris. It is a form of cellular debris or waste. It can derive from a variety of sources, primarily the glycation of proteins (i.e. a sugar bonding to a protein or lipid molecule without the controlling action of an enzyme) and also as a lipid an protein peroxidation product produced by free radical attack on cellular membranes and protein structures. The results of these rogue reactions are broken down by lysosomes resulting in the Lipofuscin that we are concerned with here.

http://en.wikipedia.org/wiki/Lipofuscin

http://en.wikipedia.org/wiki/Lysosome

'An increase in the volume of neuronal lipopigment may indicate increased functional activity of the cell, impaired removal of pigment or anoxia' (i.e. low oxygen levels).

http://bjp.rcpsych.org/cgi/content/abstract/155/1/1

Lipofuscin is not toxic in of itself, but the effect of its presence can have extremely detrimental effects on the cell and accelerate the ageing process. Lipofuscin tends to agglutinate or clump together, forming a sludge - imagine trying to play football whilst wading through water! The agglutination tends to clog up cellular membranes, reduce their fluidity and cause cellular dehydration - resulting in less efficient enzymatic cellular reactions and less efficient DNA and RNA transcription and translation. Lack of cellular membrane fluidity also results in impairment of normal Sodium, Potassium and Calcium transport in and out of the cell, reducing cellular communication (i.e. prevents synapses from releasing neurotransmitters that allow communication of information between nerve cells) and fluid flow. Dehydrated cells tend to dissipate heat less easily from enzymatic reactions. Intracellular temperatures thus tend to increase which also has the effect of increasing the amount of harmful, rogue glycation of proteins, resulting in a vicious circle of Lipofuscin build up and cellular ageing and degeneration. When Liposfuscin levels reach a critical threshold concentration the cell may die.

'[Prof. Imre Zs.Nagy]...discovered that the cells that make up young bodies comprise 92% water and lipids, and 8% dry mass. Conversely, elderly bodies comprise only 40% water and lipids, and 60% dry mass.'

www.antiaging-systems.com/ENEWS-407/centrophenoxine.htm

Lipofuscin may also absorb heavy metals such as Mercury and Aluminium as well as nutritional elements such as Zinc and Copper. Lipofuscin is there a matrix in which heavy metals are retained in the cells of the body.

Old mammamls have been demonstrated in some cases to have up to 30% of their cellular mass comprised of Lipofuscin. Lipofuscin build up tends to occur chiefly in the brain, heart muscle, smooth muscle (vascular system, bladder, reproductive tracts, GI tract, lungs, skin and eye).

Glycation products are an intermediary towards the slow formation of Advanced Glycation Endproducts (AGEs). Some AGEs are more reactive than the sugars they are derived from and are implicated in many age-related chronic diseases, e.g. cardiovascular diseases, Alzheimer's Disease, Cancer, Peripheral Neuropathy and sensory losses like Deafness. AGEs tend to interfere with molecular and cellular functioning throughout the body and result in increased oxidants. Long-lived cells such as nerve cells and brain cells, DNA, long-lasting proteins such as eye crystalline and collagen (lining blood vessels), as well as retina cells and insulin-producing beta cells are particularly at risk from damage. 'Browned' foods from baking, frying, grilling, caramelisation, or added AGEs (brown food colouring e.g. caramel in soft drinks like Cola) also are a exogenous source of AGEs.

http://en.wikipedia.org/wiki/Glycation

Professor Imre. Zs.-Nagy M.D.'s Membrane Hypothesis of Aging is summarised below.

www.antiaging-systems.com/ARTICLE-613/theories-of-aging.htm

'As we grow older the cell membrane becomes less lipid (less watery and more solid). This impedes its efficiency to conduct normal function and in particular there is a toxic accumulation. This cellular toxin is referred to as lipofuscin and as we grow older lipofuscin deposits become more present in the brain, heart and lungs and also in the skin. Indeed some of the skin age-pigments referred to as liver or age-spots (brown spots or patches that form on the skin with age) are composed of lipofuscin. It is known that Alzheimer Disease patients have much higher levels of lipofuscin deposits than compared to their healthy controls. The cells declining efficiency also means that the essential and regular transfer of sodium and potassium is impaired, thus reducing communication. It is also believed that electrical and heat transfer is also impaired. Professor Zs-Navy himself became involved in research to find substances that could aid in the removal of lipofuscin deposits and improve cellular lipidity and communication.'

The complete Membrane Hypothesis of Aging bulletin by Prof. Imre. Zs.-Nagy can be read at the link below.

www.antiaging-systems.com/ARTICLE-552/membrane-hypothesis-of-aging.htm

Zs.-Nagy emphasised that when Hydroxyl Radicals (OHRs) - a result of the interaction of Superoxide Radicals (SOR) and Hydrogen Peroxide (H2O2) from respiration - are created in confined, high-density spaces, such as cellular membranes, the probability of intermolecular cross-links increases greatly, rendering the cellular membranes, especially the mitochondrial membranes, most vulnerable to OHR attacks (by a factor of 10). Whilst most cells divide by mitosis as a defense mechanism, certain post-mitotic cells which do not divide are most vulnerable to OHR free radical attacks. These include the brain, heart and muscle cells. Continuous free radical damage to these cellular membranes can result in increased levels of dehydration, as the potassium and water permeability of the membranes decrease, resulting in less water able to get into the cells and less Potassium able to get out.

www.antiaging-systems.com/ARTICLE-501/centrophenoxine-life-extension.htm

It is contested as to whether natural mechanisms exist for the removal of Lipofuscin. The idea of lysosomal digestion is to fully break down any waste as much as possible - that is the elimination method. Lipofuscin in the end product of the digestion of certain types of lipid wastes and as such cannot be broken down enzymatically by cells any further.

It is estimated (source unknown) that for Glycation products as a whole, renal (kidney) elimination is only 30% and the half-life of a glycation product is estimated as being twice the life span of the average bodily cell. Lipofuscin levels therefore tend to increase with age, interfering with cellular functioning and communication.

The accumulation of lipofuscin-like material has been induced in rats using a protease enzyme inhibitor, and the elevated levels returned to normal after 3 months. This would indicate a disposal mechanism. However this is not strictly speaking 'true Lipofuscin', and removal of Lipofuscin has not been demonstrated in vitro. There is evidence to suggest that accumulated Lipofuscin cannot be removed from cells in vitro.

The main natural defense against Lipofuscin build up is cell death, when new cells are created (Lipofuscin-free). This may work for short-lived, replicating (mitotic) cells, but not for long-lived cells and proteins, as described above, such as brain and nerve cells etc. This is why Lipofuscin tends to accumulate in the longer-lived cells, proteins and lipid membranes, interfering with their function and causing their premature ageing and degeneration.

As far as I am aware, there are no commercially available tests for Lipofuscin levels. However, one can indirectly measure the effects of Lipofuscin levels in terms of hydration levels (total body water, extracellular water volume and exchangeable Na+ levels by radioisotope methods), plasma volume (PV) measurements (by indocyanine-green dilution test), as well as examining serum lipids and hormone and neurotransmitter levels.

For information regarding Lipofuscin removal, please see the Centrophenoxine section on the Detox page.

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Sensitivity to Heavy Metals and other Neurotoxins

There is some evidence to suggest that when the human mind is operating on a higher level that the body has much higher resistance to the damaging effects of toxic, poisonous and carcinogenic compounds, to the point of defying medical understanding. This evidence is based partly on kinesiological testing of a cigarette and virtually all participants were shown to go weak when holding the cigarette whether they smoked or not. Some participants however did not go weak when holding the cigarette and when interviewed were found to have been studying self-development techniques. Kinesiological evidence has to be evaluated carefully as in some instances, the body does not provide a clear answer as it loses clarity. Kinesiological testing is briefly examined on the Identification page.

The same principles apply to fire walking with bare feet. Clearly there are limits to how much the body can take even when the mind is positively influencing it, and a bullet to the head is clearly going to be fatal. But there is a large grey area. Some people clearly exhibit a much greater sensitivity to specific toxins or heavy metals than others in terms of the endocrine system adaptation and immune system response. However, the exact relative influence of qi levels, mental state and beliefs, biochemistry and genetics is not quite clear. They all play a part to some degree. This web site is not recommending that one ignores all the effects of toxicity by having a positive mental attitude and relying on one's belief system. But nor it is recommending that people focus entirely on medical/biochemical treatment and instill solid beliefs into their minds that they are indeed 'dirty' or 'full of toxins' inside their bodies. Instead, it is prudent to attack the problem from all angles, and actually align one's beliefs with the maximum power of the mind, and to achieve higher levels of psychological wellbeing, believing one is already well and clean and free of toxins, but whilst at the same time using all the most appropriate biochemical/herbal tools available (for example, those discussed on this page) to detoxify the body. If one has the mindset that one is already free of toxins, it may clearly 'help' the body to release more toxins rather than to hold them in as the mind has the firm belief that they are there and are hard to shift. This may sound like new age mumbo jumbo, but is doesn't cost anything and why not try it whilst engaging in your detoxification programme?

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Multiple Chemical Sensitivities (MCS):

Some people suffer from sensitivity to specific chemicals or toxins, whilst others suffer from a sensitivity to a broad range of toxins, pollutants or even strong odours (known as 'Multiple Chemical Sensitivity'). Whether this is a result of energetic, genetic, biochemical, immune system sensitivity to certain chemicals or whether it is a result of having been exposed to significant levels of these chemicals over time and built up too many toxins on the cell membranes, in the colon and in the fat cells of the body (and hence an inability to effectively remove any new toxins) is another matter. MCS is examined at the links below.

http://en.wikipedia.org/wiki/Multiple_chemical_sensitivity

http://www.multiplechemicalsensitivity.org

'Multiple Chemical Sensitivity; in broad terms it means an unusually severe sensitivity or allergy-like reaction to many different kinds of pollutants including solvents, VOC's (Volatile Organic Compounds), perfumes, petrol, diesel, smoke, "chemicals" in general and often encompasses problems with regard to pollen, house dust mites, and pet fur & dander.'

http://ohioline.osu.edu/cd-fact/0192.html

www.nap.edu/openbook.php?record_id=1988&page=35

Prof. Martin L. Pall stipulates that MCS is a response to certain organic chemical stressors, as opposed to food allergies that are an immune system response to certain types of proteins that are misinterpreted to be of viral origin. This MCS response to organic chemicals and compounds is caused up excessive NMDA upregulation, a shift in the normal Nitric Oxide/Peroxynitrite cycle, and also impaired liver function (i.e. the capability to process such toxins). Peroxynitrite formation is discussed on the Oxidative Stress page. According to Pall, the main stressors that cause MCS and this shift in the Peroxynitrite cycle in the first place are: Volatile Organic Solvent Exposure, Organophosphorus/carbamate Pesticide exposure, organochlorine pesticide exposure, pyrethroid exposure, hydrogen sulfide exposure, carbon monoxide exposure and mercury exposure. Toxicity build up from these sources in combination with an oveburdened liver can thus produce the symptoms of MCS.

www.thetenthparadigm.org/mcs09.htm

Martin Pall has suggested that exposure to the following toxic compounds (cumulative effect over long term, low level exposure (or one or more) or a single high-level exposure incident - or consecutive incidents) are implicated in the initiation of the illnesses of CFS, ME, Multiple Chemical Sensitivies, Fibromyalgia by stimulating the Nitric Oxide/Peroxynitrite cycle:

http://thetenthparadigm.org/mcs09.htm

Of course, individual cases may well have more than one stressor and not necessarily as classified above. These comorbid conditions are fluid and vary in their progression and exact nature according to the individual.

Whilst heavy metal toxicity, inefficient liver function and elevated peroxynitrite levels may well be responsible for the majority of MCS symptoms, it is likely that the immune system is also implicated, in a form of secondary immune system response, often related to the GI tract. This is discussed on the Food Intolerance page.

A healthy functioning immune system should have a healthy balance between Th1 (white blood cells) and Th2 (antibodies) activity. An immune system out of balance, e.g. Th2 overactivation, may well produce the symptoms associated with MCS and indeed certain auto-immune diseases. In some respects MCS can be considered to be the immune system over-reacting to foreign toxins, allergens, normal bacteria and parasites, and under-responding to viri, harmful yeasts, harmful intracellular bacteria and even cancer.



www.diagnose-me.com/cond/C104791.html

Dr Mark Donohoe stipulates that multiple chemical sensitivities are often instances of toxic damage or excessive neurotoxins present in the lipid compartments of the body, in particular the brain. This results in disruptions to endocrine function and immune function. These may be present perhaps because of reduced liver function (caused by over burdening and/or a build up of toxins or parasites in the liver interfering with its normal functions).

The book 'Killing Us Softly: Chemical injury & chemical sensitivity' by Dr Mark Donohoe can be downloaded at the link below (on his web site).

http://web.mac.com/doctormark/DoctorMark/KUS.html

Certain extreme reactions to food types may also be on account of food allergies brought on by candida overgrowth and/or Leaky Gut Syndrome.

Please see the Immune System Impairment page for more information regarding immune system function.

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Skin Elasticity and the 'Fountain of Youth':

The skin is one detoxification medium of the body. In a human's natural state, the skin and muscles are soft, elastic and rubbery. In an average adult they are stiffer and more rigid, without as much elasticity, and there is much more subcutaneous fluid. Only by cellular detoxification can one restore the skin and tissues natural state. It is clearly much cheaper and more effective to perform a full bodily detoxification than it is to spend money on regular skin treatments in order to restore one's natural soft skin feel and rich complexion. One other factor in skin softness and elasticity is one's internal energetic system. With a good flow of qi throughout the body, the skin will become much softer. Cellular toxification is probably one of the biggest causes of ageing and cancer. If you want to look young and feel great in your old age, then you need to detoxify your body! It isn't enough just to exfoliate the skin using expensive skin products and treatments, whilst leaving the rest of your body full of toxins.

By all means spend your money on skin treatments if you find it enjoyable and relaxing, but remember that it should not be a substitute for a proper cellular detoxification programme.

Is your body a Temple? Or is it the Temple of Doom??

Some techniques for drawing toxins from the skin and exfoliating the skin can be found in the Skin Cleansing section below. Skin Cleansing is of course only one part of an overall detoxification programme.

Free radicals damage the mitochondria (that produce the body's energy). Free radical damage shorts the life of our bodies cells and contributes to premature ageing. The number of times our somatic cells can replicate or divide are fixed or rather limited. The protective telomeres present at the end of chromosomes become shorter each time a cell divides. The telomeres maintain the viability of body/somatic cells. When they are too short they can no longer protect the chromosomes or provide the cell with the ability to divide. When the telomeres of the chromosomes that make up a cell are lost, the cell undergoes apoptosis or perish. Thus, increasing the length of the life of each cell prior to division (by consuming enough antioxidants and minimising the number of oxidants consumed/breathed in/built up in the body (i.e. toxins)) contributes to increasing one's overall life expectancy and delays the onset of ageing.

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